The results indicate that ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum. In this study, the isolated ellagic acid, gallic acid and punicaligin A&B were also examined for their effects on LPS-induced inflammation of the RAW264.7 cells. [3], Ellagic acid was first discovered by chemist Henri Braconnot in 1831. beta-Secretase (BACE1) inhibitors from pomegranate (Punica granatum) husk. The name comes from the French term acide ellagique, from the word galle spelled backwards because it can be obtained from noix de galle (galls), and to distinguish it from acide gallique (gallic acid). From this, the best cytotoxic doses were selected for further studies. NIH doi: 10.2147/IJICMR.S10200. 2013 May;33(5):341-8. doi: 10.1016/j.nutres.2013.03.003. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The name comes from the French term acide ellagique, from the word galle spelled backwards[1] because it can be obtained from noix de galle (galls), and to distinguish it from acide gallique (gallic acid). Nonsteroidal anti-inflammatory drugs: prostaglandins, indications, and side effects. 2010;2(6):266–270. Usta C, Ozdemir S, Schiariti M, Puddu PE. This site needs JavaScript to work properly. Hassani A, Azarian MMS, Ibrahim WN, Hussain SA. Ellagic acid is a polyphenol, or micronutrient, found in fruits and vegetables. Suručić R, Tubić B, Stojiljković MP, Djuric DM, Travar M, Grabež M, Šavikin K, Škrbić R. Mol Cell Biochem. Therefore, the antileishmania, cytotoxic, and immunomodulatory activities of GA and EA were evaluated in this study. A wide range of constituents of T. arjuna were characterized and broadly grouped as 27 gallic acid and 52 ellagic acid derivatives. Bioavailable constituents/metabolites of pomegranate (Punica granatum L) prefentially inhibit COX-2activity exvivo and IL-I beta induced PGE2 production in human chondrocytes in vitro. Hydrolyzable tannins break down on hydrolysis to give gallic acid and glucose or ellagic acid and glucose, known as gallotannins and ellagitannins, respectively. First, the cytotoxic effect of ellagic acid, gallic acid and punicaligin A&B on RAW264.7 cells … 2010 Jul 19;9:208. doi: 10.1186/1475-2875-9-208. Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. HHS The numerous risks associated with nonsteroidal anti-inflammatory drugs (NSAIDs) for treatment of pain and inflammation give rise to using medicinal herbs as alternative therapies. Hence, the purpose of the study was to evaluate the effect of gallic acid and ellagic acid on intestinal transport and bioavailability of linagliptin, a p-gp substrate in diabetic rats. Arch Pharm Res. Ouachrif A, Khalki H, Chaib S, Muntassir M, Abufatima R, Farouk L, Benharraf A, Chait A. Comparitive study of the anti-inflammatory and antinociceptive effects of two varieties of Punicagranatum. [9], The highest levels of ellagic acid are found in raw chestnuts, walnuts, pecans, cranberries, raspberries, strawberries, and grapes, as well as distilled beverages. 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